Stainless Steel
Bioreactor System

BR500Pro Stainless Steel Bioreactor System

Renowned for the modular design and versatile functionality, BR500Pro series stainless steel bioreactors are the best choice for pilot fermentation, with the flexibility to switch between tanks of similar sizes seamlessly, advanced SIP technology, precise pressure control, and an optional lid-lifting.

Key Facts

Interchangeable single or twin culture vessel: 10 L to 1000 L
Modular design, flexible switching different tanks with different sizes
Built-in Watson Marlow variable-speed peristaltic pumps
15.6-inch industrial resistive touchscreen
Precision control with TMFC (thermal mass flow controller)
Application for cell culture (BR500Pro-C1/C2) and microbial fermentation (BR500Pro-M1/M2)

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Modular Design with Flexibility

BR500Pro‘s modular design offers exceptional flexibility, allowing you to configure and expand the setup according to specific needs. It ensures easy customization and seamless integration, enabling efficient adaptation to different processes and applications.

Automatic Sterilization-in-Place

Siemens PLC controller automates the SIP process for the culture vessel, gas inlet, and exhaust gas flow paths through advanced program control， which ensures precise and consistent sterilization as well as enhances the safety and reliability of the bioprocess.

Turnkey System Package

With 30 years of experience, LAB1ST provides comprehensive production line for bioreaction system, including bioreactors, steam generators, CIP stations, air compressors, and chillers. Our expertise ensures reliable and efficient solutions tailored to meet the diverse needs of our customers.

Classification

BR500Pro-M1 Series

Single Configuration for Microbial Fermentation

BR500Pro-M2 Series

Twin Configuration for Microbial Fermentation

BR500Pro-C1 Series

Single Configuration for Cell Culture

BR500Pro-C2 Series

Twin Configuration for Cell Culture

The BR500PROPRO series stainless steel bioreactor is designed with a compact, skid-mounted configuration that enhances ease of installation, mobility, and space efficiency. It is available with culture vessels ranging from 10L to 500L, making it versatile for both microbial fermentation and cell culture applications. The unit features built-in fixed-speed peristaltic pumps and rotameters, a user-friendly 10.1-inch touch screen, and advanced SIP (sterilization in place) technology with precise, automatic pressure control. This all-in-one design ensures high performance and adaptability, catering to diverse operational needs.

Flexibility to switch between tanks of similar sizes seamlessly
User-friendly HMI, concise design language, simplified operation
Complies with the requirements of a validated GMP environment
4 options: specified single or twin set up, applied to microbial fermentation or cell culture

Model: BR500Pro-M1-10L ... ... BR500Pro-M1-1000L

Culture Vessel: 1 * 10 L, 15 L, 20 L, 30 L, 50 L, 100 L, 150 L, 200 L, 300 L, 500 L, 700 L, 800 L, 1000 L

Controller Capacity: Single Vessel

Application: Microbial Fermentation

Model: BR500Pro-C1-10L ... ... BR500Pro-C1-500L

Culture Vessel: 1 * 10 L, 15 L, 20 L, 30 L, 50 L, 100 L, 150 L, 200 L, 300 L, 500 L

Controller Capacity: Single Vessel

Application: Cell Culture

For detailed technical parameters, please contact us or download the specifications.

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Microbial Fermentation

Utilizing two flow paths for air and O2 flow, the flow meter intuitively indicates and allows manual adjustment of the sparger flow rate. O2 is pulsed through a solenoid valve and flows only as needed to maintain the Dissolved Oxygen (DO) set point.

No air is provided at this time. A mass flow controller can be integrated to measure and control the total gas flow range by manual adjustment or automatically combined with a DO controller.

Cell Culture

Simultaneous gassing strategy of overlay and sparger: air goes into overlay through a flow meter and a solenoid valve. Solenoid valves select air, O2, N2 and CO2 to flow to the sparger.

An additional airflow path can be added to the distributor. Mass flowmeter is optional for each gas inlet.

Gassing Strategy Diagram for Microbial Fermentation

Gassing Strategy Diagram for Cell Culture

Complete Software Functions

Siemens PLC controller, stable, reliable and easy to maintain;
Automatic sterilization-in-place (SIP) of the culture vessel, gas inlet and exhaust gas flow path;
Control capacities: Manual/automatic control, PID control, correlation control, step control, custom recipe setting;
Measurement and control opportunities of pH, DO, temperature, foam, feed, gas mixing, agitation, harvest and constant total gas flow control, etc.;
PH control uses time judgment to avoid the mutual addition of CO2 and alkali;
Different software versions, corresponding to C and M series, corresponding to cell culture and fermentation applications;
Real-time online monitoring, data recording, curve display of various parameters;
Automatic storage of operation records, traceability of experimental process,etc.;
3-level password protection ensures data security;
USB (software updates, serial communication), Ethernet (IP Network)

Powerful Hardware Configuration

10.1-inch color touch screen for real-time monitoring and control of bioprocess parameters;
A full set of Hamiltion / Metteler sensors with high precision, supporting repeated sterilization, and facilitating process development and optimization;
Servo Motors: High-precision, maintenance-free, low-noise servo motors for long-term stable operation;
Fast load pump heads for fast and secure handling of tubings;
Individual flow meters with optional TMFC (mass flow controller) precisely adjust gas flow rate;
Quick-connect couplings make it easy to attach all cables and supplies to the culture vessels;

Mature Culture Vessel Design

Material: tank SUS316L (polishing better than Ra 0.4 um), jacket SUS304, insulation SUS304 (aluminum silicate filled)
Stainless steel tank with insulation layer, safe and energy-saving;
Complete tank cover interface configuration, rich and flexible functional ports to meet different process requirements;
Prepared with CIP (Cleaning in Place) interface, allowing the operator to effectively, reproducibly and automatically clean the complete system including the culture vessel, gas inlets, exhaust lines, addition lines and transfer groups;
4-Valve addition array, disposable sampling valves and drain valves are either manually or automatically sterilized;
Equipped with an easy-to detach condenser around the air outlet, for easy cleaning, no effusion and no contaminating bacteria;

Analysis or Control: OUR, CER, KLa, RQ, ORP, methanol, exhaust gas (O2, CO2), glucose, ect.
Gas Supply Control: TMFC control (flow rate - automatic)
Peristaltic Pump: More peristaltic pumps for different functions; upgrade to Watson-Marlow peristaltic pump heads
Scale: Tank weight / replenishing
Light: Light source can be selected from red, blue, and white. Its intensity is adjustable [0-100%]
Drive: Top magnetic drive
Electric lid lifting device enables the easy removal of the lid and allows simple and safe handling during cleaning work or when culture vessel accessories are changed.
Remote Function: Option to upgrade remote monitoring and screen mirroring; Realize remote software upgrade
Different sizes and styles of tanks (mechanical or magnetic stirring, different stirring paddles) to adapt to different process requirements
Dual temperature PID control of jacket and tank ensures stable temperature control and high precision;