Bench-top
Bioreactor System

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BR100Pro Bench-top Bioreactor System

Designed to meet validated lab research requirements, BR100Pro bench-scale bioreactor features a 15.6-inch industrial resistive touch screen for easy operation and ensures stable performance with the integration of high precision Watson Marlow feeding pumps and smart gassing strategy.

Key Facts

Interchangeable single or twin culture vessel: 1 L to 15 L
Built-in Watson Marlow variable-speed peristaltic pumps
15.6-inch industrial resistive touchscreen
Precision control with MFC (mass flow controller)
Culture vessel with heating blanket
Stainless steel 304 or white-color powder outer enclosure
Application for cell culture (BR100Pro-C1/C2) and microbial fermentation (BR100Pro-M1/M2)

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Features

Remarkable Adaptability

BR100Pro controller tower offers remarkable adaptability, supporting culture vessels of difference sizes with just one controller. This versatility allows for multi-purpose use, making it an ideal choice for diverse applications.

Advanced Control & Flexibility

Featuring advanced configurations like the Watson Marlow variable speed peristaltic pumps and a MFC (Thermal Mass Flow Controller), BR100Pro system ensures precise and adaptable control over your bioprocesses.

Monitoring Extendability

Equipped with an analog input supporting a 4-20 mA range, the BR100Pro bioreactor ensures precise monitoring of additional parameters tailored to your needs, enhancing process accuracy and flexibility.

Classification

BR100Pro-M1 Series

Single Configuration for Microbial Fermentation

BR100Pro-C1 Series

Single Configuration for Cell Culture

BR100Pro-M2 Series

Twin Configuration for Microbial Fermentation

BR100Pro-C2 Series

Twin Configuration for Cell Culture

BR100Pro series bench scale bioreactors are designed to meet the requirements of validated lab research requirements. This system combines precision and flexibility. It is not only equipped with one MFC and adjustable variable speed pump to ensure precise control, but also the controller can switch to control different sizes of kettles.

Ideal for lab upgrades: high-precision control, accuracy, and scalability.
User-friendly HMI, concise design language, simplified operation
4 options: Interchangeable single or twin set up, applied to microbial fermentation or cell culture
Complies with the requirements of a validated GMP environment

Model: BR100Pro-M1-3L ... ... BR100Pro-M1-15L

Culture Vessel: 1 * 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Single vessel

Application: Microbial Fermentation

Model: BR100Pro-M2-3L ... ... BR100Pro-M2-15L

Culture Vessel: 2 * 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Twin vessels

Application: Microbial Fermentation

Model: BR100Pro-C1-3L ... ... BR100Pro-C1-15L

Culture Vessel: 1 * 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Single vessel

Application: Cell culture

Model: BR100Pro-C2-1L ... ... BR100Pro-C2-15L

Culture Vessel: 2 * 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Twin vessels

Application: Cell culture

For detailed technical parameters, please contact us or download the specifications.

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Microbial Fermentation - O2-Enrichment

Utilizing two flow paths for air and O2 flow, the flow meter intuitively indicates and allows manual adjustment of the sparger flow rate. O2 is pulsed through a solenoid valve and flows only as needed to maintain the Dissolved Oxygen (DO) set point. No air is provided at this time.

A mass flow controller can be integrated to measure and control the total gas flow range by manual adjustment or automatically combined with a DO controller.

Sparger - Air: Max. design 1vvm
Sparger - O2: Max. design 0.2vvm

Gassing Strategy Diagram for Microbial Fermentation

Cell Culture - Additive Flow

Simultaneous gassing strategy of overlay and sparger: air goes into overlay through a flow meter and a solenoid valve. Solenoid valves select air, O2, N2 and CO2 to flow to the sparger. An additional airflow path can be added to the distributor. Mass flowmeter is optional for each gas inlet.

Overlay - Air: Max. design 1vvm
Sparger - Air: Max. design 0.2vvm
Sparger - O2: Max. design 0.2vvm
Sparger - N2: Max. design 0.2vvm
Sparger - CO2: Max. design 0.2vvm
Rotameter accuracy: ± 4%
MFC accuracy: ± 1% [Upgradable ± 0.5%]

Gassing Strategy Diagram for Cell Culture

Powerful Hardware Configuration

15.6-inch industrial resistive touchscreen, easy-to-use and reliable operation even while wearing laboratory gloves;
A full set of Hamiltion / Metteler sensors with high precision, supporting repeated sterilization, and facilitating process development and optimization;
Servo Motors: High-precision, maintenance-free, low-noise servo motors for long-term stable operation;
Watson Marlow variable-speed Peristaltic Pumps for fast tubing installations;
Precision control with MFC (mass flow controller) ;
Quick-connect couplings make it easy to attach all cables and supplies to the culture vessels;
All inlets and ports for cooling water, process gases, electricity, Ethernet, and potential-free alarm contacts are located on the side panel of the control tower

Mature Culture Vessel Design

Material: SUS316L stainless steel, high-quality borosilicate glass, EPDM/silicone seals, reliable airtightness, clean and hygienic design;
Round shaped bottom of the stand provides a maximum of sturdiness to the vessel;
The heating blanket can be easily wrapped around vessel and secured tightly by hook and connectors for optimal heat transfer.
Complete tank cover interface configuration, rich and flexible functional ports to meet different process requirements;
Complete dish-washer proof stirrer enables cleaning of the head plate in a dishwasher without removing the stirrer shaft;
Additional, integrated handles make it more ergonomic and easier to carry;
Equipped with an easy-to detach condenser around the air outlet, for easy cleaning, no effusion and no contaminating bacteria.

Complete Software Functions

Siemens PLC controller, stable, reliable and easy to maintain;
Different software versions, corresponding to C and M series, corresponding to cell culture and fermentation applications;
Measurement and control opportunities of pH, DO, temperature, foam, feed, gas mixing, agitation, harvest and constant total gas flow control, etc.;
Control capacities: Manual/automatic control, PID control, correlation control, step control, custom recipe setting;
Real-time online monitoring, data recording, curve display of various parameters;
Automatic storage of operation records, traceability of experimental process, etc.;
3-level password protection ensures data security;
USB (software updates, serial communication), Ethernet (IP Network)
With 1 analogue input, 4~20mA

Analysis or Control: OUR, CER, KLa, RQ, ORP, methanol, exhaust gas (O2, CO2), glucose, etc.
Gas Supply Control: Up to 5 MFCs (Vogtlin), optional burkert or Alicat brands
Scale: Tank weight / replenishing
Light: Light source can be selected from red, blue, and white. Its intensity is adjustable [0-100%]
Remote Function: Option to upgrade remote monitoring and screen mirroring.
Realize remote software upgrade

Vessel Type: Jacketed round bottom cylindrical tank + water jacket
temperature control
Drive: Top magnetic drive
Height-to-diameter ratio: 1.5:1 | 2.5:1 | 3:1
Aeration Microsparger
Material Carbon steel + plastic powder coating
Blades: Customizable blades from different options (Spin filter, Cell-lift）