Bench-top
Bioreactor System

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NEW BR100 Bench-top Bioreactor System

Tailored for small-scale bioprocessing, NEW BR100 bench-scale bioreactor system offers a versatile and user-friendly platform for both cell culture and microbial fermentation applications.

It features autoclavable culture vessels ranging from 500 ml to 15 L. Designed with budget-conscious newcomers in mind, it provides a complete, user-friendly package for research and development.

Key Facts

Specified single or twin set-up for control of one or two culture vessel
Built-in fixed-speed peristaltic pumps
Easy to read 10.1-inch touch screen
Mechanical stirring culture vessel with heating base
Application for cell culture (BR100-C1/C2) and microbial fermentation (BR100-M1/M2)

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Caractéristiques

Experience precision and reliability

Achieve precision and reliability with our Siemens PLC controller, high quality electrical components, high-precision Hamilton/Mettler sensors, and maintenance-free, low-noise servo motors—ensuring stable, efficient operation and easy maintenance.

Modular and Flexible Design

Compact and efficient, this bench-top bioreactor fits perfectly on any lab bench. With easy access to all components, it ensures hassle-free transport to and from the autoclave, even in smaller units. Upgrade your lab with this space-saving solution!

Economical and Convenient Package

Budget-conscious design for newcomers starting research with a complete package includes a bench-scale bioreactor, compact autoclave, lab-grade air compressor, and cooling circulator. All essential accessories, such as sensors, tubing, and spargers, are also included.

Classification

BR100-M1 Series

Single Configuration for Microbial Fermentation

BR100-M2 Series

Twin Configuration for Microbial Fermentation

BR100-C1 Series

Single Configuration for Cell Culture

BR100-C2 Series

Twin Configuration for Cell Culture

BR100 bench-scale bioreactor system is perfect for research and development, which is available with single or twin culture vessels, and a capacity range from 500ml to 15L, this system. Its built-in fixed-speed peristaltic pumps ensure consistent fluid handling, while the 10.1-inch touch screen provides an intuitive interface for real-time monitoring and control. With specific models designed for cell culture (BR100-C1/C2) and microbial fermentation (BR100-M1/M2), this bioreactor system meets the diverse needs of modern bioprocessing.

Quickly begin your experiments, without breaking the budget
User-friendly HMI, concise design language, simplified operation
Complies with the requirements of a validated GMP environment
4 options: specified single or twin set up, applied to microbial fermentation or cell culture

Model: BR100-M1-1L ... ... BR100-M1-15L

Culture Vessel: 1 * 500 ml, 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Single vessel

Application: Microbial Fermentation

Model: BR100-M2-1L ... ... BR100-M2-15L

Culture Vessel: 2 * 500 ml, 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Twin vessels with same size

Application: Microbial Fermentation

Model: BR100-C1-1L ... ... BR100-C1-15L

Culture Vessel: 1 * 500 ml, 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Single vessel

Application: Cell culture

Model: BR100-C2-1L ... ... BR100-C2-15L

Culture Vessel: 2 * 500 ml, 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Twin vessels with same size

Application: Cell culture

For detailed technical parameters, please contact us or download the specifications.

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Microbial Fermentation - O2-Enrichment

Utilizing two flow paths for air and O2 flow, the flow meter intuitively indicates and allows manual adjustment of the sparger flow rate. O2 is pulsed through a solenoid valve and flows only as needed to maintain the Dissolved Oxygen (DO) set point. No air is provided at this time.

A mass flow controller can be integrated to measure and control the total gas flow range by manual adjustment or automatically combined with a DO controller.

Sparger - Air: Max. design 1vvm
Sparger - O2: Max. design 0.2vvm

Gassing Strategy Diagram for Microbial Fermentation

Cell Culture - Additive Flow

Simultaneous gassing strategy of overlay and sparger: air goes into overlay through a flow meter and a solenoid valve. Solenoid valves select air, O2, N2 and CO2 to flow to the sparger. An additional airflow path can be added to the distributor. Mass flowmeter is optional for each gas inlet.

Overlay - Air: Max. design 1vvm
Sparger - Air: Max. design 0.2vvm
Sparger - O2: Max. design 0.2vvm
Sparger - N2: Max. design 0.2vvm
Sparger - CO2: Max. design 0.2vvm
Rotameter accuracy: ± 4%
MFC accuracy: ± 1% [Upgradable ± 0.5%]

Gassing Strategy Diagram for Cell Culture

Powerful Hardware Configuration

10.1-inch color touch screen for real-time monitoring and control of bioprocess parameters;
A full set of Hamiltion / Metteler sensors with high precision, supporting repeated sterilization, and facilitating process development and optimization;
Servo Motor: High-precision, maintenance-free, low-noise servo motor for long-term stable operation;
Fast load pump heads for fast and secure handling of tubings;
Quick-connect couplings make it easy to attach all cables and supplies to the culture vessels;

Mature Culture Vessel Design

Material: SUS316L stainless steel, high-quality borosilicate glass, EPDM/silicone seals, reliable airtightness, clean and hygienic design;
Mechanical stirring culture vessel with heating base;
Complete tank cover interface configuration, rich and flexible functional ports to meet different process requirements ;
Complete dish-washer proof stirrer enables cleaning of the head plate in a dishwasher without removing the stirrer shaft;
Equipped with an easy-to detach condenser around the air outlet, for easy cleaning, no effusion and no contaminating bacteria.
Additional, integrated handles make it more ergonomic and easier to carry;

Complete Software Functions

Siemens PLC controller, stable, reliable and easy to maintain;
Different software versions, corresponding to C and M series, corresponding to cell culture and fermentation applications;
Measurement and control opportunities of pH, DO, temperature, foam, feed, gas mixing, agitation, harvest and constant total gas flow control, etc.;
Control capacities: Manual/automatic control, PID control, correlation control, step control, custom recipe setting;
Real-time online monitoring, data recording, curve display of various parameters;
Automatic storage of operation records, traceability of experimental process,etc.;
3-level password protection ensures data security;
USB (software updates, serial communication), Ethernet (IP Network)

Analysis or Control: OUR, CER, KLa, RQ, ORP, methanol, exhaust gas (O2, CO2), glucose, etc.
Gas Supply Control: Up to 5 MFCs (Vogtlin), optional burkert or Alicat brands
Scale: Tank weight / replenishing
Light: Light source can be selected from red, blue, and white. Its intensity is adjustable [0-100%]
Remote Function: Option to upgrade remote monitoring and screen mirroring.
Realize remote software upgrade

Vessel Type: Jacketed round bottom cylindrical tank + water jacket
temperature control
Drive: Top magnetic drive
Height-to-diameter ratio: 1.5:1 | 2.5:1 | 3:1
Aeration Microsparger
Material Carbon steel + plastic powder coating
Blades: Customizable blades from different options (Spin filter, Cell-lift）