Bench-top
Bioreactor System

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BR100 Bench-top Bioreactor System

Tailored for small-scale bioprocessing, BR100 bench-scale bioreactor system offers a versatile and user-friendly platform for both cell culture and microbial fermentation applications.

It features autoclavable culture vessels ranging from 1L to 15 L. Designed with budget-conscious newcomers in mind, it provides a complete, user-friendly package for research and development.

Key Facts

Cost-effective and standardized solution
Built-in fixed-speed peristaltic pumps
Easy to read 10.1-inch touch screen
Mechanical stirring culture vessel with heating base
Application for cell culture (BR100-C1/C2) and microbial fermentation (BR100-M1/M2)

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Caractéristiques

Experience precision and reliability

Achieve precision and reliability with our Siemens PLC controller, high quality electrical components, high-precision Hamilton/Mettler sensors, and maintenance-free, low-noise servo motors—ensuring stable, efficient operation and easy maintenance.

Modular and Flexible Design

Compact and efficient, this bench-top bioreactor fits perfectly on any lab bench. With easy access to all components, it ensures hassle-free transport to and from the autoclave, even in smaller units. Upgrade your lab with this space-saving solution!

Economical and Convenient Package

Budget-conscious design for newcomers starting research with a complete package includes a bench-scale bioreactor, compact autoclave, lab-grade air compressor, and cooling circulator. All essential accessories, such as sensors, tubing, and spargers, are also included.

Classification

BR100-M1 Series

Single Configuration for Microbial Fermentation

BR100-M2 Series

Twin Configuration for Microbial Fermentation

BR100-C1 Series

Single Configuration for Cell Culture

BR100-C2 Series

Twin Configuration for Cell Culture

BR100 bench-scale bioreactor system is perfect for research and development, which is available with single or twin culture vessels, and a capacity range from 1L to 15L, this system. Its built-in fixed-speed peristaltic pumps ensure consistent fluid handling, while the 10.1-inch touch screen provides an intuitive interface for real-time monitoring and control. With specific models designed for cell culture (BR100-C1/C2) and microbial fermentation (BR100-M1/M2), this bioreactor system meets the diverse needs of modern bioprocessing.

Comprehensive control including manual, automatic, sequential, cascaded, conditional, etc. meet different experimental needs.
Multiple cascades for DO control by means of agitation speed, oxygen bypass, and feed, increasing process control flexibility.
Up to 24 recipes, with no theoretical upper limit on steps, to achieve automatic operation of the biological process.
Easily perform online calibration for sensor and peristaltic pump ensures accurate and reliable process control.
Extensible real-time display trend chart for easily viewing your entire biological process
Complete batch data, alarm and operation records, easy to query, export and backup. With 8G ROM, data can be saved for many years.
Three-level authority management and upper & lower limit alarm settings reduce risks.
Wireless and wired LAN communication, easily realize remote monitoring and control.
M2 series: Supporting recipe sharing, synchronized comparison of parameter curves, and synchronized setting and control of parameters

Model: BR100-M1-1L ... ... BR100-M1-15L

Culture Vessel: 1 * 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Single vessel

Application: Microbial Fermentation

Model: BR100-M2-1L ... ... BR100-M2-15L

Culture Vessel: 2 * 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Twin vessels with same size

Application: Microbial Fermentation

Model: BR100-C1-1L ... ... BR100-C1-15L

Culture Vessel: 1 * 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Single vessel

Application: Cell culture

Model: BR100-C2-1L ... ... BR100-C2-15L

Culture Vessel: 2 * 1 L, 2 L, 3 L, 5 L, 7 L, 10 L, 15 L

Controller Capacity: Twin vessels with same size

Application: Cell culture

For detailed technical parameters, please contact us or download the specifications.

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Microbial Fermentation - O2-Enrichment

Two Gas Sources (Air & Oxygen) + Bottom Sparger

Air Supply: Manually regulated by a rotameter.
Oxygen Supply:
- Manually regulated by a rotameter.
- Automated on/off control via solenoid valve.
Gas Delivery:
- Both gas streams merge into a single line.
- Pass through a 0.2 μm sterile filter.
- Enter the vessel via a bottom-mounted ring sparger for efficient gas-liquid contact.

Gassing Strategy Diagram for Microbial Fermentation

Cell Culture - Additive Flow

Four Gas Sources (Air, CO₂, N₂, O₂) + Dual Delivery (Overlay & Sparger)

Air Supply – Overlay (Surface Aeration)
- A split air stream is manually adjusted via a rotameter.
- Filtered through a 0.2 μm sterile filter.
- Delivered to the headspace (overlay) of the vessel.
Bottom Sparging System
- Air: Manually controlled via rotameter
- O₂, N₂, CO₂: Each gas manually adjusted via individual rotameter and flow automatically regulated by solenoid valve (on/off control)
- All four gases (Air + O₂ + N₂ + CO₂) merge into a single line and passes through a 0.2 μm sterile filter.
- Enters the vessel via a bottom ring sparger for efficient gas-liquid contact.

Gassing Strategy Diagram for Cell Culture

Powerful Hardware Configuration

10.1-inch color touch screen for real-time monitoring and control of bioprocess parameters;
A full set of Hamiltion sensors (DO, pH) with high precision, supporting repeated sterilization, and facilitating process development and optimization;
Servo Motor: High-precision, maintenance-free, low-noise servo motor for long-term stable operation;
Fast load pump heads for fast and secure handling of tubings;
Quick-connect couplings make it easy to attach all cables and supplies to the culture vessels;

Mature Culture Vessel Design

Material: SUS316L stainless steel, high-quality borosilicate glass, EPDM/silicone seals, reliable airtightness, clean and hygienic design;
Mechanical/magnetic stirring culture vessel with heating base;
Complete tank cover interface configuration, rich and flexible functional ports to meet different process requirements ;
Complete dish-washer proof stirrer enables cleaning of the head plate in a dishwasher without removing the stirrer shaft;
Equipped with an easy-to detach condenser around the air outlet, for easy cleaning, no effusion and no contaminating bacteria.
Additional, integrated handles make it more ergonomic and easier to carry;

Complete Software Functions

Siemens PLC controller, stable, reliable and easy to maintain;
Different software versions, corresponding to C and M series, corresponding to cell culture and fermentation applications;
Measurement and control opportunities of pH, DO, temperature, foam, feed, gas mixing, agitation, harvest and constant total gas flow control, etc.;
Control capacities: Manual/automatic control, PID control, correlation control, step control, custom recipe setting;
Real-time online monitoring, data recording, curve display of various parameters;
Automatic storage of operation records, traceability of experimental process,etc.;
3-level password protection ensures data security;
USB (software updates, serial communication), Ethernet (IP Network)

Analysis or Control: OUR, CER, KLa, RQ, ORP, methanol, exhaust gas (O2, CO2), glucose, etc.
Gas Supply Control: Up to 5 MFCs
Scale: Tank weight / replenishing
Light: Light source can be selected from red, blue, and white. Its intensity is adjustable [0-100%]
Remote Function: Option to upgrade remote monitoring and screen mirroring.
Realize remote software upgrade

Vessel Type: Jacketed round bottom cylindrical vessel + water jacket
temperature control
Drive: Top magnetic drive
Height-to-diameter ratio: 1.5:1 | 2.5:1 | 3:1
Aeration Microsparger
Material Carbon steel + plastic powder coating
Blades: Customizable blades from different options (Spin filter, Cell-lift）