SUB500 Series Single-use Bioreactors
The single-use bioreactor, derived from stainless steel bioreactor technology, simplifies operations and reduces the risk of cross-contamination in the cultivation of various cell lines.
SUB500 is a stirred-tank, disposable bioreactor for cultivating human, mammalian, and animal cells. It combines the efficiency of single-use systems with the high performance of conventional stainless steel bioreactors. The single-use design eliminates tedious cleaning, sterilization, and reducing setup times. The unique stirring system brings better gas transfer and liquid mixing, thus achieving faster production speed and a higher yield. With a wide volume range from 50L to 2000L, TheSUB500 is a perfect choice for trial, pilot-scale or industrial scale applications.
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Designed based on the mixing principle of conventional bioreactor
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Process equipment is free from cleaning and sterilization verification
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Straight axis impeller reactor with low shearing force
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Specification: 50L-2000L
Features
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Smart Control System
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Siemens PLC Control System: Implements PID closed-loop control with cell culture-compliant sensors and hardware.
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15" Touchscreen Interface: Enables local operation, real-time data display, dual-data backup, and power-off protection.
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GMP-Compliant Software: Meets GAMP5 and 21 CFR Part 11 requirements for pharmaceutical production.
Bioreactor Tank Design
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Low-Shear Axial Mixing: Gentle paddle design ensures uniform cell suspension and efficient gas dispersion.
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Precision Temperature Control: PT1000 sensor with jacket and TCU maintains stable conditions with safety protections.
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Optimized Cell Growth: Combines mixing and temperature control for ideal culture conditions.
Premium Quality
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Integrated Bioreactor System: Axial-flow mixing with modular design enables stable operation and customization.
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Intelligent Control Interface: User-friendly touchscreen with secure access and automated data recording.
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Dual Aeration Technology: Combines top overlay and bottom sparging for optimal cell growth conditions.
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Designed for SUB straight axis stirred bioreactor
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Electrode interfaces are reserved for the reactor flexibly, including replenishing, PH, DO and temperature electrode interfaces
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Optional bubbling mode;
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Culture bag uses 9101 film; double-layer package and after gamma irradiation sterilization
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Volume: 50L to 2000L;
Specifications
Model | SUB500-C-50 | SUB500-C-200 | SUB500-C-500 | SUB500-C-1000 | SUB500-C-2000 |
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Max. volume (L) | 68 | 280 | 700 | 1300 | 2800 |
Max. working volume (L) | 50 | 200 | 500 | 1000 | 2000 |
Speed accuracy (rpm) | ±0.5 rpm | ±0.5 rpm | ±0.5 rpm | ±0.5 rpm | ±0.5 rpm |
Speed range (rpm) | 0-240 | 0-150 | 0-110 | 0-90 | 0-70 |
Optimal operating speed (rpm) | 70-140 | 60-100 | 50-80 | 40-70 | 35-60 |
Total power (kW) | 1.5 | 1.5 | 2.5 | 2.5 | 7.5 |
Electrical supply | 220V 50Hz | 220V 50Hz | 220V 50Hz | 220V 50Hz | 220V 50Hz |
Max. H/D ratio | 1.3 | 1.34 | 1.23 | .36 | 1.29 |
Max. liquid level (mm) | 480 | 783 | 1005 | 1360 | 1670 |
Internal vessel height (mm) | 662 | 1050 | 1335 | 2365 | |
Internal vessel diameter (mm) | 370 | 585 | 815 | 997 | 1295 |
Min. working volume (L) | 12.5 | 50 | 125 | 250 | 500 |
Frequently Asked Questions