SUB500 Series Single-use Bioreactors
The single-use bioreactor, derived from stainless steel bioreactor technology, simplifies operations and reduces the risk of cross-contamination in the cultivation of various cell lines.
SUB500 is a stirred-tank, disposable bioreactor for cultivating human, mammalian, and animal cells. It combines the efficiency of single-use systems with the high performance of conventional stainless steel bioreactors. The single-use design eliminates tedious cleaning, sterilization, and reducing setup times. The unique stirring system brings better gas transfer and liquid mixing, thus achieving faster production speed and a higher yield. With a wide volume range from 50L to 2000L, TheSUB500 is a perfect choice for trial, pilot-scale or industrial scale applications.
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Built with load cell system
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Intuitive and clear Siemens display
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Pre-sterilized, no cleaning required
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Modular design ensures easy scale-up
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On-line measurement of DO and PH
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Fully scalable from 50L to 2000L
Features
User-friendly Operation
The intuitive color-touch screen makes it easy to set, control and monitor all the parameters. The single-use design ensures user-friendly operation and easy maintenance, and the entire bag can be easily disconnected using a sterile disconnection method.
Easy Scale-up
The SUB500 series single-use bioreactor has a wide volume range from 50L to 2000L, providing an easy transition from lab scale to commercial scale. Its consistent performance across different volumes simplifies the scale-up process.
Premium Quality
Each part of the single-use bioreactor is built keeping the quality in mind. The single-use bag is made from Renolit membrane and has passed multiple of compliance testing. The results show our bioreactor fully meets the culture needs of HEK293, CHO, and SF9 cells.
The single-use bag is made from RENOLIT membrane which offers excellent gas permeability and chemical stability, ensuring optimal cell growth conditions. It is suitable for mammalian and insect cell cultures, making it ideal for processes in antibody production, vaccine development, and cell and gene therapies
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Volume: 5L to 100L
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Temperature Range: 8℃ to 40℃
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Excellent gas permeability
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Outstanding biocompatibility
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Lightweight and flexible
Specifications
Controller
SUB500-C-50L
65
50
25
0.2
30~200
0~10
0~5
0~5
0~5
SUB500-C-100L
131
100
50
0.2
30~200
0~10
0~5
0~5
0~5
.
SUB500-C-250L
316
250
125
0.2
30~150
0~10
0~5
0~5
0~5
SUB500-C-500L
660
500
250
0.4
30~150
0~20
0~10
0~10
0~10
SUB500-C-1000L
1320
1000
500
0.4
20~110
0~20
0~10
0~10
0~10
±5%
0~14
0~300
Support two-point calibration and online calibration.
Vessel
Volume (L)
Nominal Working Volume (L)
Min. Working Volume (L)
Motor Power (KW)
Control
Speed Range (RPM)
Temperature Control Range (℃)
Air flow meter control range (Overlay) (L)
Air flow meter control range (Sparger) (L)
O2 flow meter control range (L)
CO2 flow meter control range (L)
Flow meter control accuracy
pH meassurement and control range (pH)
DO meassurement and control range (%)
Calibration
SUB500-C-2000L
2575
2000
1000
0.4
20~90
0~50
0~45
0~30
0~15
25~37
Single-use Bags
Volume（L）
Max. Working Volume（L）
Min. Working Volume（L）
Impeller Diameter（mm）
Max. Rotating Speed（RPM）
SUB500-RB-50L
50
50
25
110
150
SUB500-RB-100L
100
100
50
111
150
SUB500-RB-250L
250
250
125
190
150
SUB500-RB-500L
500
500
250
244
120
SUB500-RB-1000L
1000
1000
500
320
90
SUB500-RB-2000L
2000
2000
1000
397
75
Frequently Asked Questions